5-甲基-1H-苯并[d]咪唑-1-羧酸叔丁酯

5-甲基-1H-苯并[d]咪唑-1-羧酸叔丁酯 - Names and Identifiers

Name	1H-Benzimidazole-1-carboxylic acid, 5-methyl-, 1,1-dimethylethyl ester
Synonyms	1-Boc-5-Methyl-1H-benzimidazole tert-Butyl 5-methyl-1H-benzimidazole-1-carboxylate tert-Butyl 5-methyl-1H-benzo[d]imidazole-1-carboxylate 1H-Benzimidazole-1-carboxylic acid, 5-methyl-, 1,1-dimethylethyl ester 1H-BenziMidazole-1-carboxylic acid, 5-Methyl-, 1,1-diMethylethyl ester
CAS	863877-81-0

5-甲基-1H-苯并[d]咪唑-1-羧酸叔丁酯 - Physico-chemical Properties

Molecular Formula	C13H16N2O2
Molar Mass	232.28
Storage Condition	2-8°C

5-甲基-1H-苯并[d]咪唑-1-羧酸叔丁酯 - Introduction

Acid, 5-methyl-, 1,1-dimethyl ester is an organic compound with the chemical formula of C17H20N2O2. It is a white crystalline solid with low solubility.

Its main use is as a protecting group in organic synthesis. It can be used as an acyl protecting reagent to protect the potential affinity point on the nitrogen atom during the synthesis of active compounds. The Boc protecting group can be introduced by reacting the azo acid, 5-methyl-, 1,1-dimethylethyl ester with the substrate, thereby protecting the active group in the substrate. When desired, the Boc protecting group can be removed by acidic conditions under certain conditions.

The preparation of acid, 5-methyl-, 1,1-dimethyl ester can be carried out in multiple steps. First, 5-methylbenzimidazole carboxylic acid is reacted with sodium hydroxide to form the corresponding sodium salt. Then, it reacts with tert-butyl iodoformate to produce acid, 5-methyl-, 1,1-dimethyl ester.

Pay attention to the safety information when using acid, 5-methyl-, 1,1-dimethyl ester. It may have an irritating effect on the skin, eyes and respiratory tract. Wear chemical protective gloves, goggles and gas mask during operation. Avoid direct contact and inhalation. In addition, during storage and disposal, care should be taken to prevent fire and avoid contact with oxidants.

Last Update：2024-04-10 22:29:15